science
Target inflammation, disrupt aging and disease progression
Aging Mechanisms
Breakthrough research in Sinclair Lab and others revealed aging pathways converging to inflammation.
Inflammation Pathways
Therapeutics targeting immune system have generated abundant clinical data, which Immetas is leveraging to develop drugs that modulate innate and adaptive immune responses
Targeting chronic inflammation has broad therapeutic potential in age-associated disease conditions
Prevalence of cardiovascular, respiratory, cancer, metabolic and immune-mediated disorders increase with age.
European Respiratory Journal 2014 44: 1332-1352
Aging is associated with remodeling of the immune system and profound changes in the cytokine network.
Adult
Middle-aged adults present a well-balanced profile between innate and adaptive immune responses with an equal contribution of pro-inflammatory and anti-inflammatory cytokine-producing cells
Elderly
Changes in the cytokine pattern in the elderlies are characterized by prominent contribution of the innate immune response
Immunity & Ageing (2017) 14:2